With Merseyside currently in Tier 2 of the UK Government’s latest COVID-19 restrictions, 2,000 Toffees supporters will be allowed into Goodison Park for the game.
The Reds beat Everton 3-1 in the league last month and the victors of this tie will progress to the last four, which is due to be played in early January.
Here’s everything you need to know ahead of the clash…
HOW CAN I FOLLOW THE GAME?
The game kicks off at 20:00 GMT and will be broadcast on Sky Sports in the UK. United supporters will also be able to follow all the action from Merseyside on ManUtd.com and in our Official App, where you can also track in-game data using our Match Centre.
MUTV will provide build-up, live radio commentary and post-match reaction as well as showing full reruns of the game the following day.